Shanghai guard Peng Szu-Chin hobbled off the court, seemingly through a strain, just one minute into the second half. Without one of its main scorers, Shanghai could not catch up on the offensive end as Xinjiang pulled away through backcourt combo Wang Siyu and Wang Lili's efforts.
Zhejiang's Shan Wanli made six 3-pointers on nine attempts to score a game-high 29 points. Wang Haimei chipped in with 13.
Shanxi gradually gained the upper hand in the second quarter before going eight points up at the break.
Shanxi had a 10-3 dash in the midway of the last quarter, bringing the game beyond Hebei's reach.
The 45-year-old Li, who spent his entire playing career with Luneng, was one of the key members in China's only World Cup experience in 2002. As a player, Li helped Luneng win one Chinese top-flight title, three CFA Cup titles and one CSL Cup title.
Insufficient defense marked by only 29 rebounds compared to 53 by the visitor proved to be the key element that led to Handlova's second defeat and put it at the bottom of the rankings.
Mainz failed to put up any resistance while Union relentlessly tripled their lead after Marvin Friedrich headed home Christopher Trimmel's free-kick in the 63rd minute for 3-0.
The 2018 champion lost to Anisimova in the quarterfinals in Paris last year, but this time the Romanian needed only 54 minutes to complete a convincing victory.
Nadal will face Sebastian Korda, the son of 1998 Australian Open winner Petr Korda, in the next round. The American youngster secured his first appearance in a Grand Slam round of 16 by beating fellow qualifier Pedro Martinez 6-4, 6-3, 6-1 to advance.
Five Dongguan players scored in the double-digits. Dilana Dilishati had 19 points and eight boards. Shen Yi scored 18 points and dished out eight assists.
"I don't know what happened actually, I felt like I was playing perfectly, I was so focused the whole match, even I am surprised that I can do that," said the 54th-ranked Swiatek, who fired 30 winners and won 81 percent of her first-serve to wrap up the victory.